Please can You help me Get The answer to My question

Please I’m coming here for help, because I’m so extremely frustrated. I have been searching the internet to trying to find the answer to my question and I can’t get the answer. How long after you stop taking Nexium does it take to leave your system and for the side effects go away? Please I have been on Nexium for 6 six months and I have now just stop taking it, because I have Nummular eczema. My dermatologist thought I was having a reaction to the new soap we are using at my job. I have been using Cetaphil Restoraderm Pro wash and the I still have the Nummular eczema, I was taken off the nexium. Please can anyone help me to find the answer to my quest? I would greatly appreciate any help you can give me.


Each person's reaction to the medication may be different and it may take time to recover from side effects.  Your doctor or pharmacist can give you the best answer to your question and advise on how to speed up the healing process.  


This 2014 Harvard Health Letter doesn’t address your question about side effects from Nexium, but it quotes a gastroenterologist who says a PPI (like Nexium) “will be out of your system within a week.”

https://www.health.harvard.edu/digestive-health/should-you-keep-taking-that-heartburn-medication


you can ask a pharmacist...they should know about OTC meds also...but I have caught them being uneducated on Rx meds....


Here's some laboratory data on Nexium (omeprazole). It can cause some skin irritation although I could not find specific mention of nummular eczema - but that does NOT mean it is impossible. Each person is different and just 'cause the text book says it shouldn't...

Anyway, the active drug itself leaves your system quickly. Definitely within a couple days. The breakdown products take a bit longer but they don't do the same thing as the parent compound you take as a drug to fix something like acid problems in the GI tract. The body's response to the drug (intended effect as well as side effects) over 6 months may take longer to reverse. That also means the original problem can come back.

The bottom line (as shown in the end of the abstract):

The half-life, with a maximum of approximately 3 h, is too short to cause accumulation when the drug is administered in a once-daily regimen.

Message me off line for more discussion.

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https://www.ncbi.nlm.nih.gov/pubmed/2315973

The pharmacokinetics of omeprazole, hydroxyomeprazole, omeprazolesulfone, and "remaining metabolites" have been studied in eight young healthy subjects following an acute i.v. and oral dose of 10 and 20 mg of 14C-labeled drug, respectively. The oral dose was given as a buffered solution. Two subjects exhibited essentially higher and more sustained plasma levels of omeprazole than the others. This was due to a higher bioavailability, lower clearance, and longer t1/2 of omeprazole in these two subjects. Maximum concentration (0.7-4.6 mumol/L) was reached between 10 and 25 min after oral dosing. The median bioavailability was 39% (25-117%) and the median systemic plasma clearance was 624 ml/min (range of 59-828 ml/min). The corresponding t1/2 for the i.v. dose was 35 min (16-150 min) and 39 min (14-186 min) after oral administration. The drug was rapidly distributed to extravascular sites (mean t1/2 lambda 1 = 3.0 +/- 0.8 min). Mean Vss was 0.23 +/- 0.04 L/kg. Low systemic clearance of omeprazole was associated with a decreased formation rate of hydroxyomepraxole and "remaining metabolites" while omeprazolesulfone formation seemed to be less affected. However, there was a clear-cut correlation between the t1/2 of omeprazole and of its omeprazolesulfone metabolite, indicating that the elimination of these two compounds is mediated by the same isoenzyme. The mean urinary recovery of the radioactive dose during 96 h was 78.3 +/- 2.3 and 75.7 +/- 2.6% for the i.v. and oral dose, respectively. Insignificant amounts were due to unchanged drug and omeprazolesulfone. The excretion of hydroxyomeprazole during the first 12 h varied between 4.6 to 15.5% of a given dose. The mean recovery of radioactivity in the feces was 19.3 +/- 3.1% of a given i.v. dose and 18.2 +/- 2.3% when given orally. It is concluded that omeprazole is mainly eliminated metabolically and that there is a substantial interindividual variation in the rate of formation of primary and secondary metabolites. This variation in omeprazole disposition is probably of limited clinical importance. The half-life, with a maximum of approximately 3 h, is too short to cause accumulation when the drug is administered in a once-daily regimen.




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